Antimicrobial activity and synergism of Sami-Hyanglyun-Hwan with ciprofloxacin against methicillin-resistant Staphylococcus aureus
10.1016/j.apjtm.2015.06.010
- Author:
Jang-Gi CHOI
1
;
Ok-Hwa KANG
1
;
Dong-Yeul KWON
1
;
Jang-Gi CHOI
2
;
Preeti BHARAJ
2
;
Ji-Young CHOI
3
;
Myong-Soo CHONG
3
;
Su-Hyun MUN
4
;
Dong-Won SHIN
5
Author Information
1. Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Wonkwang Oriental Medicines Research Institute
2. Center of Excellence in Infectious Disease Research, Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center
3. Department of Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University
4. BK21 Plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University
5. Department of Oriental Medicine Resources, Sunchon National University
- Publication Type:Journal Article
- Keywords:
Ciprofloxacin;
Methicillin-resistant Staphylococcus aureus;
Sami-Hyanglyun-Hwan;
Synergy
- From:
Asian Pacific Journal of Tropical Medicine
2015;8(7):538-542
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the antibacterial activity of SHH extracted with either water or ethanol against methicillin-resistant Staphylococcus aureus (MRSA) and combinatory antimicrobial effect with ciprofloxacin (CIP) by time kill assay and checkerboard dilution test. Methods: The antibacterial activity determined by broth dilution method indicated that the antibacterial activity of Sami-Hyanglyun-Hwan (SHH) water extract (SHHW) and SHH ethanol extract (SHHE) ranged from 250 to 2. 000 μg/mL and 125 to 1. 000 μg/mL against MRSA, respectively. Results: In the checkerboard method, the combinations of SHHE with CIP had a partial synergistic or synergistic effect against MRSA. The time-kill curves showed that a combined SHHE and CIP treatment reduced the bacterial counts dramatically after 24 h. Conclusions: The present study demonstrates the therapeutic ability of SHHE against MRSA infections.
