Netrin-1: The new tumor markers in renal clear cell carcinoma
10.1016/j.apjtm.2015.05.005
- Author:
Bai-Sheng GONG
1
;
Qiang FENG
1
Author Information
1. Uropoiesis Surgical Department, Sichuan Academy of Medical Sciences Sichuan Province People's Hospital
- Publication Type:Journal Article
- Keywords:
Netrin-1;
Renal clear cell carcinoma;
Tumor marker
- From:
Asian Pacific Journal of Tropical Medicine
2015;8(6):489-493
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the expression of Netrin-1 protein in human renal clear cell carcinoma (RCCC) and the relationships between Netrin-1, pathology and prognosis. Methods: 72 cases of RCCC admitted in our hospital from 2008 June to 2009 June and their adjacent tissues were selected for study. They included 30 cases in stage I-II, 42 cases in stage III-IV; 9 cases in grade I, 9 cases in grade II, 40 cases in grade III and 14 cases in grade IV. All cases were followed up for more than 5 years. Survival analysis lines were made by Kaplan-Meier method and the difference between groups was tested by the Log-rank test. The expression of Netrin-1 protein was detected by immunohistochemistry staining and its clinical significance was analyzed. Results: Renal clear cell carcinoma: 51 cases in high expression of Netrin-1 and 21 cases in low expression, normal tissues: 12 cases in high expression of Netrin-1 and 60 cases in low expression, the difference between the two groups is significant (χ2=42.921, P<0.01). The difference of the expression of Netrin-1in Fuhrman grade and AJCC clinical stage is significant (χ2=8.000, χ2=6.203; P<0.05). The 5-year survival rate in low protein expression group and in high protein expression group was 79% (17/21) and 62% (32/51). The survival curve had different trend, with no significant difference between groups ((χ2=1.360, P=0.245). Conclusions: Netrin-1 protein plays an important role in the development of RCCC. It might be a new specific tumor marker of RCCC, and might become a new target in treatment of RCCC.
