Antiprotozoal assessment and phenolic acid profiling of five Fumaria (fumitory) species
10.1016/S1995-7645(14)60331-X
- Author:
Ilkay Erdogan ORHAN
1
;
Bilge SENER
1
;
Nilgun OZTURK
2
Author Information
1. Department of Pharmacognosy, Faculty of Pharmacy, Gazi University
2. Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University
- Publication Type:Journal Article
- Keywords:
Antiprotozoal;
Fumaria;
Fumitory;
Malaria;
Phenolic acid;
Trypanosomiasis
- From:
Asian Pacific Journal of Tropical Medicine
2015;8(4):283-286
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore some Fumaria species which were recorded to be traditionally used against malaria and other protozoal diseases. Methods: Consequently, in the current study, antiprotozoal effect of the ethanol extracts obtained from five Fumaria species (Fumaria densiflora, Fumaria cilicica, Fumaria rostellata, Fumaria kralikii, and Fumaria parviflora) was investigated against the parasites; Plasmodium falciparum (malaria) and Trypanosoma bruceirhodesiense (human African trypanosomiasis) at 0.81 and 4.85 μg/mL concentrations. Results: Among them, Fumaria densiflora extract exerted the highest antiplasmodial (93.80%) and antitrypanasomal effect (55.40%), while the ethanol extracts of Fumaria kralikii (43.45%) and Fumaria rostellata (41.65%) showed moderate activity against Plasmodium falciparum. Besides, phenolic acid contents of the extracts were analyzed using high performance liquid chromatography (HPLC) and trans-cinnamic (4.32 mg/g) and caffeic (3.71 mg/g) acids were found to be the dominant phenolic acids in Fumaria densiflora. Conclusions: According to our results, Fumaria densiflora deserve further study for its promising antiprotozoal activity.
