Effects of gentiana scabra bage on expression of hepatic type I, III collagen proteins in Paragonimus skrjabini rats with liver fibrosis
10.1016/S1995-7645(14)60188-7
- Author:
Zhao-Xia QU
1
;
Fang LI
2
;
Chao-Dong MA
3
;
Jun LIU
4
;
Wen-Lin WANG
4
;
Shu-De LI
5
Author Information
1. Zhenjiang Medical School
2. Yuncheng Nursing Vocational College
3. First People's Hospital in Zhenjiang
4. Department of Parasitology, Faculty of Basic Medicine, Kunming Medical University
5. Department of Biochemistry and Molecular Biology, Faculty of Basic Medicine, Kunming Medical University
- Publication Type:Journal Article
- Keywords:
Collagen protein I;
Collagen protein III;
Gentiana scabra bage;
Liver fibrosis;
Paragonimus skrjabini
- From:
Asian Pacific Journal of Tropical Medicine
2015;8(1):60-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effects of gentiana scabra bage on the expression of hepatic collagen proteins in Paragonimus skrjabini rats with liver fibrosis. Methods: Immunohistochemical technique was used to observe the changes of content of hepatic type I, III collagen proteins in Paragonimus skrjabini rats with liver fibrosis before and after the gentiana scabra bage treatmeat. Results: Comparing with the model group, changes of hepatic type I and type III collagen proteins in gentiana scabra bage treated group were significantly weakened. Conclusions: Gentiana scabra bage treatment can reduce the content of hepatic type III and type I collagen protein significantly in Paragonimus skrjabini rats with liver fibrosis, thereby, playing the role against hepatic fibrosis.
