MicroRNA-126 inhibits the proliferation of lung cancer cell line A549
10.1016/S1995-7645(14)60323-0
- Author:
Xun YANG
1
;
Bei-Bei CHEN
1
;
Ming-Hua ZHANG
1
;
Xin-Rong WANG
1
Author Information
1. Respiratory Department, Central Hospital of Wuhan
- Publication Type:Journal Article
- Keywords:
MicroRNA-126;
Proliferation;
VEGF
- From:
Asian Pacific Journal of Tropical Medicine
2015;8(3):239-242
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the role of microRNA-126 in the development of lung cancer. Methods: The biological function of microRNA-126 was detected using EdU assay and CCK-8 assay; the target gene of microRNA-126 was analyzed using real time RT-PCR and Western blot assay. Results: In A549 cell line, overexpression of microRNA-126 inhibits the proliferation rate; VEGF is the target gene of microRNA-126; microRNA-126 exerts its function via regulating VEGF protein level. Conclusions: microRNA-126 inhibits the proliferation in A549 cell line.
