Effect of thioredoxin-interacting protein on Wnt/β-catenin signaling pathway and diabetic myocardial infarction
10.1016/j.apjtm.2015.10.010
- Author:
Hui YU
1
;
Xian-Xian ZHAO
1
;
Xing-Hua SHAN
1
;
Pan LI
1
;
Tao CHEN
1
Author Information
1. Cardiovascular Department, Changhai Hospital Affiliated to Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Diabetes;
Myocardial infarction;
Thioredoxin-interacting protein;
β-catenin
- From:
Asian Pacific Journal of Tropical Medicine
2015;8(11):976-982
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the regulatory role of thioredoxin-interacting protein (TXNIP) in Wnt/β-catenin signaling pathway and therefore to elucidate its function in diabetic myocardial infarction. Methods: Diabetic myocardial infarction models were generated in mice. The expression levels of TXNIP and β-catenin and level of reactive oxygen species (ROS) were determined and compared with those in control group. Human umbilical vein endothelial cells were treated with high-concentration glucose and/or silencing TXNIP and/or H
