Is glucose-6-phosphate dehydrogenase deficiency more prevalent in Carrion's disease endemic areas in Latin America?
10.1016/j.apjtm.2015.11.014
- Author:
Fernando MAZULIS
1
;
Claudia WEILG
1
;
Carlos ALVA-URCIA
1
;
Maria J. PONS
1
;
Juana DEL VALLE MENDOZA
1
Author Information
1. School of Medicine, Research Center of the Health Sciences Faculty, Universidad Peruana de Ciencias Aplicadas (UPC)
- Publication Type:Journal Article
- Keywords:
Bartonella;
Febrile syndrome;
G6PD;
Glucose-6-phosphate dehydrogenase
- From:
Asian Pacific Journal of Tropical Medicine
2015;8(12):1079-1080
- CountryChina
- Language:Chinese
-
Abstract:
Glucose-6-phosphate dehydrogenase (G6PD) is a cytoplasmic enzyme with an important function in cell oxidative damage prevention. Erythrocytes have a predisposition towards oxidized environments due to their lack of mitochondria, giving G6PD a major role in its stability. G6PD deficiency (G6PDd) is the most common enzyme deficiency in humans; it affects approximately 400 million individuals worldwide. The overall G6PDd allele frequency across malaria endemic countries is estimated to be 8%, corresponding to approximately 220 million males and 133 million females. However, there are no reports on the prevalence of G6PDd in Andean communities where bartonellosis is prevalent.
