Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection
10.1016/j.apjtm.2015.12.002
- Author:
Thomas PUTTI
1
;
Benny K.H. TAN
1
;
Vincent T. CHOW
1
;
Thomas PUTTI
2
;
Benny K.H. TAN
2
;
Vincent T. CHOW
2
;
Thomas PUTTI
3
;
Benny K.H. TAN
3
;
Vincent T. CHOW
3
Author Information
1. Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore
2. Department of Pathology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore
3. Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore
- Collective Name:Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore;Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore;Department of Pathology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore;Department of Pathology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore;Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore;Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore
- Publication Type:Journal Article
- Keywords:
Cinanserin;
Dengue virus;
Houttuynia cordata;
Murine coronavirus;
Quercetin;
Quercetrin
- From:
Asian Pacific Journal of Tropical Medicine
2016;9(1):1-7
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the in vitro activities of the ethyl acetate (EA) fraction of Houttuynia cordata (H. cordata) Thunb. (Saururaceae) and three of its constituent flavonoids (quercetin, quercitrin and rutin) against murine coronavirus and dengue virus (DENV). Methods: The antiviral activities of various concentrations of the EA fraction of H. cordata and flavonoids were assessed using virus neutralization tests against mouse hepatitis virus (MHV) and DENV type 2 (DENV-2). Cinanserin hydrochloride was also tested against MHV. The EA fraction of H. cordata was tested for acute oral toxicity in C57BL/6 mice. Results: The EA fraction of H. cordata inhibited viral infectivity up to 6 d. Cinanserin hydrochloride was able to inhibit MHV for only 2 d. The 50% inhibitory concentrations (IC
