Relationship between CD14-159C/T gene polymorphism and acute brucellosis risk
10.1016/j.apjtm.2016.01.036
- Author:
Mehdi MOGHADAMPOUR
1
;
Mehdi MOGHADAMPOUR
2
;
Ebrahim ESKANDARI-NASAB
3
;
Ebrahim ESKANDARI-NASAB
4
;
Fatemeh SHABANI
5
Author Information
1. Department of Microbiology, School of Medicine, Zahedan University of Medical Sciences
2. Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences
3. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences
4. Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences
5. School of Medicine, Jiroft University of Medical Sciences
- Publication Type:Journal Article
- Keywords:
Acute brucellosis;
Cluster of differentiation 14;
Single nucleotide polymorphism
- From:
Asian Pacific Journal of Tropical Medicine
2016;9(3):247-251
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the association between the cluster of differentiation 14 (CD14)-159C/T (rs2569190) gene polymorphism and susceptibility to acute brucellosis in an Iranian population. Methods: The study included 153 Iranian patients with active brucellosis and 128 healthy individuals as the control group. Genotyping of the CD14 variant was performed using an amplification refractory mutation system-polymerase chain reaction method. Results: The prevalence of CD14-159 TT and CT genotypes were associated with increased risk of brucellosis [odds ratio (OR) = 1.993, 95% confidence interval (95% CI) = 1.07-3.71, P = 0.03 for CT; OR = 3.869, 95% CI = 1.91-7.84, P = 0.01 for TT genotype. Additionally, the minor allele (T) was significantly more frequently present in brucellosis patients than in controls (61% vs. 45%, respectively), and was a risk factor for brucellosis (OR = 3.058, 95% CI = 1.507-6.315, P = 0.01). Conclusions: The findings provided suggestive evidence of association of the CD14-159C/T gene polymorphism with susceptibility to acute brucellosis in the Iranian population.
