Mechanism of all-transretinoic acid increasing retinoblastoma sensitivity to vincristine
10.1016/j.apjtm.2016.01.028
- Author:
Yan JIANG
1
;
Lin ZHANG
1
Author Information
1. Department of Ophthalmology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Publication Type:Journal Article
- Keywords:
All-transretinoic acid;
Apoptosis;
Cell cycle;
Retinoblastoma;
Vincristine
- From:
Asian Pacific Journal of Tropical Medicine
2016;9(3):278-282
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the mechanism of all-transretinoic acid (ATRA) increasing retinoblastoma (RB) sensitivity to vincristine, and the inhibiting effect of vincristine combined with ATRA treatment on the SO-RB50 cell proliferation. Methods: SO-RB50 cells were cultivated by routine culture method. Different concentrations of vincristine or ATRA were added into culture solution. After 48 h, cell counting kit-8 was used to detect the median inhibitory concentration (IC
