Phylogeny of Murray Valley encephalitis virus in Australia and Papua New Guinea

Eleonora Cella; Marta Giovanetti; Alessandra Lo Presti; Massimo Ciccozzi; Eleonora Cella; Ivan Gabrielli; Gianguglielmo Zehender; Alessia Lai; Marta Giovanetti; Giordano Dicuonzo; Silvia Angeletti; Marco Salemi; Massimo Ciccozzi

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Phylogeny of Murray Valley encephalitis virus in Australia and Papua New Guinea

Author: Eleonora CELLA ¹ ; Marta GIOVANETTI ¹ ; Alessandra Lo PRESTI ¹ ; Massimo CICCOZZI ¹ ; Eleonora CELLA ² ; Ivan GABRIELLI ³ ; Gianguglielmo ZEHENDER ⁴ ; Alessia LAI ⁴ ; Marta GIOVANETTI ⁵ ; Giordano DICUONZO ⁶ ; Silvia ANGELETTI ⁶ ; Marco SALEMI ⁷ ; Massimo CICCOZZI ⁸
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1. Department of Infectious, Parasitic and Immunomediated Diseases, National Institute of Health
2. Department of Public Health and Infectious Diseases, Sapienza University of Rome
3. University of Rome 'La Sapienza'
4. L. Sacco Department of Biomedical and Clinical Sciences, University of Milan
5. University of Rome 'Tor Vergata'
6. Clinical Pathology and Microbiology Laboratory, University Hospital Campus Bio-Medico of Rome
7. Department of Pathology and Laboratory Medicine, University of Florida
8. University Hospital Campus Bio-Medico
Publication Type:Journal Article
Keywords: Evolution; Murray valley encephalitis virus; Phylogeny
From: Asian Pacific Journal of Tropical Medicine 2016;9(4):385-389
CountryChina
Language:Chinese
Abstract: Objective: To study the genetic diversity of Murray Valley encephalitis virus (MVEV) in Australia and Papua New Guinea. Methods: MVEV envelope gene sequences were aligned using Clustal X and manual editing was performed with Bioedit. ModelTest v. 3.7 was used to select the simplest evolutionary model that adequately fitted the sequence data. Maximum likelihood analysis was performed using PhyML. The phylogenetic signal of the dataset was investigated by the likelihood mapping analysis. The Bayesian phylogenetic tree was built using BEAST. Results: The phylogenetic trees showed two main clades. The clade I including eight strains isolated from West Australia. The clade II was characterized by at least four epidemic entries, three of which localized in Northern West Australia and one in Papua New Guinea. The estimated mean evolutionary rate value of the MVEV envelope gene was 0.407 × 10