Hepatoprotective properties of oleanolic and ursolic acids in antitubercular drug-induced liver damage
10.1016/j.apjtm.2016.05.015
- Author:
Gabriel A. GUTIÉRREZ-REBOLLEDO
1
;
Adelina JIMÉNEZ-ARELLANES
1
;
A. Georgina SIORDIA-REYES
2
;
Mariana MECKES-FISCHER
3
Author Information
1. Unidad de Investigación Médica en Farmacología (UIMF), UMAE Hospital de Especialidades, Centro Médico Nacional-Siglo XXI (CMN-SXXI), Instituto Mexicano del Seguro Social (IMSS)
2. Servicio de Patología, UMAE Hospital de Pediatría, CMN-SXXI, IMSS
3. Centro de Diagnóstico en Metabolismo Energético y Medicina Mitocondrial, A.C.
- Publication Type:Journal Article
- Keywords:
Antitubercular drugs;
Hepatoprotector effect;
Oleanolic acid;
Triterpenes;
Ursolic acid
- From:
Asian Pacific Journal of Tropical Medicine
2016;9(7):644-651
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimate to what extent the mixture of ursolic acid and oleanolic acid, in addition to the antitubercular standard regime, affects the hepatotoxicity profile. Methods Liver injury was induced in male BALB/c mice by administering, per os and daily for 11 weeks, a combination of anti-Tubercular (anti-TB) agents Rifampicin (10 mg/kg), Isoniazid (10 mg/kg), and Pyrazinamide (30 mg/kg). The ursolic acid and oleanolic acid mixture at doses of 100 or 200 μg/mouse/day was subcutaneously injected throughout the entire study period (11 weeks). Biochemical and hematological analysis was supplemented by liver histological examination. Results Animals treated with the mixture of triterpenic acids exhibited significantly decreased aspartate transaminase and alanine aminotransferase levels and amelioration of the histopathological alterations produced by the anti-TB drugs. Conclusions The triterpene mixture was able to prevent the steatosis induced by the anti-TB drugs.
