CETP polymorphisms confer genetic contribution to centenarians of Hainan, south of China
10.1016/j.apjtm.2016.07.009
- Author:
Yun-Xia ZHANG
1
;
Dai-Feng ZHOU
1
;
Yi-Min QIU
1
;
Wang-Wei CAI
1
;
Ya SU
2
;
Li TANG
3
;
Ze-Xing YANG
3
Author Information
1. Department of Biochemistry and Molecular Biology, Hainan Medical College
2. Hainan Cadre Sanatorium/Geriatric Hospital of Hainan
3. Department of Reproduction and Genetics, The First Affiliated Hospital of Kunming Medical University
- Publication Type:Journal Article
- Keywords:
Centenarians;
Genetic contribution;
Polymorphisms of CETP
- From:
Asian Pacific Journal of Tropical Medicine
2016;9(9):872-876
- CountryChina
- Language:Chinese
-
Abstract:
Objective In this paper, we will discuss if the CETP polymorphism contributes to the centenarians in Hainan island. Methods We tested the TaqIB and I405V polymorphisms of CETP gene among 276 centenarians and 301 matched healthy individuals by AS-PCR and analyzed the data with SPSS software package (Version 19.0). Results Our data indicated that allele B1 and V have the significant differences between centenarians and healthy control groups with P < 0.001. Further analysis implied that genotypes B1B1 (P < 0.001, OR = 0.148, 95% CI = 0.095-0.230) and VV (P < 0.001 and OR = 0.353, 95% CI = 0.237-0.525) were significantly different between centenarians and matched controls. The combination of B and V, such as B1B1-II (P < 0.001, OR = 0.128, 95% CI = 0.049-0.329), B1B1-IV (P < 0.001, OR = 0.115, 95% CI = 0.056-0.237), B1B2-VV (P < 0.05, OR = 0.534, 95% CI = 0.310-0.920), and B2B2-VV (P < 0.001, OR = 0.198, 95% CI = 0.086-0.453) have significant differences between centenarians and matched healthy individuals from Hainan. Conclusion Our results implied that allele B1B1 and VV, as well as the combination B1B1-II, B1B1-IV, B1B2-VV and B2B2-VV may contribute to the longevity in centenarians of Hainan, south of China.
