Effect of emodin on mobility signal transduction system of gallbladder smooth muscle in Guinea pig with cholelithiasis
10.1016/j.apjtm.2016.07.021
- Author:
Bang-Jiang FANG
1
;
Jun-Yi SHEN
1
;
Shuang ZHOU
2
;
Hua ZHANG
3
;
Chuan-Zhu LYU
3
;
Yi-Qiang XIE
4
Author Information
1. Emergency Department, Long Hua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
2. Changhai Hospital of Traditional Chinese Medicine, Second Military University
3. Traumatology Department, Affiliated Hospital of Hainan Medical University
4. College of Traditional Chinese Medicine, Hainan Medical University
- Publication Type:Journal Article
- Keywords:
Dynamics of biliary tract;
Emodin;
Gallbladder;
Guinea pig;
Signal transduction
- From:
Asian Pacific Journal of Tropical Medicine
2016;9(10):1013-1018
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of emodin on protein and gene expressions of the massagers in mobility signal transduction system of cholecyst smooth muscle cells in guinea pig with cholesterol calculus. Methods The guinea pigs were randomly divided into 4 groups, such as control group, gall-stone (GS) group, emodin group and ursodeoxycholic acid (UA) group. Cholesterol calculus models were induced in guinea pigs of GS, emodin and UA groups by lithogenic diet, while emodin or UA were given to the corresponding group for 7 weeks. The histomorphological and ultrastructure change of gallbladder were detected by microscope and electron microscope, the content of plasma cholecystokinin (CCK) and [Ca
