Evaluation of interleukin 8 +2767 A/T polymorphism in visceral leishmaniasis
10.1016/j.apjtm.2016.09.010
- Author:
Alireza AHMADI
1
;
Mohammad ABASI
1
;
Alireza KHALILIAN
1
;
Mohammad MATINI
1
;
Khosro SARDARIAN
1
;
Mehrdad HAJILOOI
2
;
Ghasem SOLGI
2
;
Ahad BAZMANI
2
Author Information
1. Department of Internal Medicine, School of Medicine, Hamadan University of Medical Sciences
2. Department of Immunology, Faculty of Medicine, Hamadan University of Medical Sciences
- Publication Type:Journal Article
- Keywords:
Interleukin 8;
Polymorphism;
Visceral leishmaniasis
- From:
Asian Pacific Journal of Tropical Medicine
2016;9(11):1075-1077
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluated the relationship between the genetic variations at IL-8 +2767 position with VL pathogenesis among Iranian patients. Methods Three groups including patients with VL clinical presentation and leishmania seropositive (n = 124), patients seropositive but without clinical presentation (n = 82) and healthy controls (n = 63) were selected to conduct this cross-sectional study. Polymorphism at +2767 position of IL-8 was investigated using PCR-RFLP techniques. Anti-leishmania antibody titration was evaluated by the immunoflorescence technique. Results We observed higher significant frequencies +2767 A/A and A/T genotypes in Group 1 compared to Group 2 and healthy controls (P = 0.001). Also, patients in Group 1 carrying A/A genotype showed higher titer of anti-leishmania antibody than patients with A/T and T/T genotypes (P = 0.05). The validity of the data was analyzed using Hardy–Weinberg equilibrium and one way analysis of variance (ANOVA), as well as χ
