Acetylcholinesterase, butyrylcholinesterase and paraoxonase 1 activities in rats treated with cannabis, tramadol or both
10.1016/j.apjtm.2016.09.009
- Author:
Omar M.E. ABDEL-SALAM
1
;
Eman R. YOUNESS
2
;
Yasser A. KHADRAWY
3
;
Amany A. SLEEM
4
Author Information
1. Department of Toxicology and Narcotics, National Research Centre
2. Department of Medical Biochemistry, National Research Centre
3. Department of Physiology, National Research Centre
4. Department of Pharmacology, National Research Centre
- Publication Type:Journal Article
- Keywords:
Cannabis sativa;
Cholinesterases;
Cognitive decline;
Memory;
Tramadol
- From:
Asian Pacific Journal of Tropical Medicine
2016;9(11):1089-1094
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Cannabis sativa resin and/or tramadol, two commonly drugs of abuse on acetylcholinesterase and butyrylcholinesterase activities as a possible cholinergic biomarkers of neurotoxicity induced by these agents. Methods Rats were treated with cannabis resin (5, 10 or 20 mg/kg) (equivalent to the active constituent Δ
