Medical plant extracts and natural compounds with a hepatoprotective effect against damage caused by antitubercular drugs: A review
10.1016/j.apjtm.2016.10.010
- Author:
María Adelina JIMÉNEZ-ARELLANES
1
;
Gabriel Alfonso GUTIÉRREZ-REBOLLEDO
1
;
Mariana MECKES-FISCHER
1
;
Rosalba LEÓN-DÍAZ
1
Author Information
1. Unidad de Investigación Médica en Farmacología, UMAE Hospital de Especialidades, Centro Médico Nacional-Siglo XXI, Instituto Mexicano del Seguro Social
- Publication Type:Journal Article
- Keywords:
Antitubercular drugs-induced hepatotoxicity;
Hepatoprotective effect;
Medicinal plants;
Natural compounds
- From:
Asian Pacific Journal of Tropical Medicine
2016;9(12):1141-1149
- CountryChina
- Language:Chinese
-
Abstract:
Drug-induced liver injury encompasses a spectrum of diseases ranging from mild biochemical abnormalities to acute liver failure; example of this scenery is hepatotoxicity caused by the first-line antituberculous drugs isoniazid, rifampin and pyrazinamide, which are basic for treatment of drug-sensible and drug-resistant tuberculosis. In the search for pharmacological alternatives to prevent liver damage, antitubercular drugs have been the subject of numerous studies and published reviews, a great majority of them carried out by Asian countries. At the same time, hepatoprotectors from plant source are now emerging as a possible alternative to counteract the toxic effects of these therapeutic agents. The present review aims to highlight the most recent studies on the subject, based information published in scientific databases such as Scopus and PubMed.
