Genetic association study of P2x7 A1513C (rs 3751143) polymorphism and susceptibility to pulmonary tuberculosis: A meta-analysis based on the findings of 11 case–control studies
10.1016/j.apjtm.2016.11.006
- Author:
Eyad M.A. ALSHAMMARI
1
;
Saif KHAN
1
;
Raju K. MANDAL
2
;
Mohd WAHID
2
;
Sajad A. DAR
2
;
Arshad JAWED
2
;
Mohammed Y. AREESHI
2
;
Shafiul HAQUE
2
;
Sajad A. DAR
3
;
Md. Ekhlaque Ahmed KHAN
4
;
Aditya K. PANDA
4
Author Information
1. Department of Clinical Nutrition, College of Applied Medical Sciences, University of Ha'il
2. Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University
3. The University College of Medical Sciences & GTB Hospital (University of Delhi)
4. Centre for Life Sciences, Central University of Jharkhand
- Publication Type:Journal Article
- Keywords:
Genetic model;
Meta-analysis;
P2x7 gene;
Polymorphism;
Pulmonary tuberculosis
- From:
Asian Pacific Journal of Tropical Medicine
2016;9(12):1150-1157
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the precise association between pulmonary tuberculosis (PTB) and P2x7 A1513C gene polymorphism. Methods PubMed and Google Scholar web-databases were searched for the studies reporting the association of P2x7 A1513C polymorphism and PTB risk. A meta-analysis was performed for the selected case–control studies and pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for all the genetic models. Results Eleven studies comprising 2 678 controls and 2 113 PTB cases were included in this meta-analysis. We observed overall no significant risk in all the five genetic models. When stratified population by the ethnicity, Caucasian population failed to show any risk of PTB in all the genetics models. In Asian ethnicity, variant allele (C vs. A: P = 0.001; OR = 1.375, 95% CI = 1.159–1.632) and heterozygous genotype (AC vs. AA: P = 0.001; OR = 1.570, 95% CI = 1.269–1.944) demonstrated significant increased risk of PTB. Likewise, recessive genetic model (CC + AC vs. AA: P = 0.001; OR = 1.540, 95% CI = 1.255–1.890) also demonstrated increased risk of PTB in Asians. Conclusions Our meta-analysis did not suggest the association of P2x7 A1513C polymorphism with PTB risk in overall or separately in Caucasian population. However, it plays a significant risk factor for predisposing PTB in Asians. Future larger sample and expression studies are needed to validate this association.
