Phytocompounds of Anonna muricata leaves extract and cytotoxic effects on breast cancer cells
- Author:
Husna Syakirah Ab RAHMAN
1
;
Michael Pak-Kai WONG
1
;
Mohd Ridzuan Abdul SAMAD
1
;
Mohd Nizam Md HASHIM
1
;
Wan Suriyani WAN-IBRAHIM
2
;
Norzila ISMAIL
2
;
Siti Farhanah MOHD-SALLEH
2
;
Tuan Nadrah ISMAIL
3
Author Information
- Publication Type:Journal Article
- Keywords: Annona muricata; Anti-proliferative; Breast cancer; GCMS; Graviola
- From: Asian Pacific Journal of Tropical Medicine 2018;11(12):659-665
- CountryChina
- Language:Chinese
- Abstract: Objective: To identify the phytochemical compounds from Annona muricata (A. muricata) and to determine their in vitro anti-proliferative activities against breast cancer cells, MCF7 and MDA-MB-231. Methods: A. muricata leaves were successively extracted by soxhlet method using n-hexane, ethyl acetate and methanol, and decocted with water. Each extract was analysed by gas chromatography mass spectrometry (GCMS) and characterized with Wiley and NIST library searches. Anti-proliferative activity of each extract was evaluated on MCF7 and MDA-MB-231 breast cancer cells using MTT assay. Results: The GCMS analysis of different solvent extracts of A. muricata leaves showed presence of different chemical groups of compounds such as steroids, terpenoids, phenolic compounds, sugars, sugars alcohol and others including vitamin E. Ethyl acetate leaves extract exhibited the lowest IC
