Cytotoxic, antioxidant and antimicrobial activities of Nerium oleander collected in Morocco

Messaoudi Mouhcine; Benbacer Laila; El Mzibri Mohammed; Messaoudi Mouhcine; Amzazi Saaid; Laglaoui Amin; Hammani Khalil

Return

Cytotoxic, antioxidant and antimicrobial activities of Nerium oleander collected in Morocco

Author: Messaoudi MOUHCINE ¹ ; Benbacer LAILA ¹ ; El Mzibri MOHAMMED ¹ ; Messaoudi MOUHCINE ² ; Amzazi SAAID ² ; Laglaoui AMIN ³ ; Hammani KHALIL ⁴
Author Information

1. Unité de Biologie et Recherche Médicale, CNESTEN
2. Laboratoire de Biochimie-Immunologie, Faculté des Sciences, Mohammed v University
3. Équipe de Recherche en Biotechnologies and Génie des Biomolécules, Faculté des Sciences et Techniques de Tanger, Abdelmalek Essaadi University
4. Laboratoire de Ressources Naturelles et Environnement, Faculté Polydisciplinaire de Taza, Sidi Mohammed Ben Abdellah University
Publication Type:Journal Article
Keywords: Antimicrobial; Antioxidant; Bioactive compounds; Cytotoxicity; Nerium oleander; nti-cancer
From: Asian Pacific Journal of Tropical Medicine 2019;12(1):32-37
CountryChina
Language:Chinese
Abstract: Objective: To investigate the cytotoxic, antioxidant and antibacterial activities of ethanolic and aqueous crude extracts of Nerium oleander (N. oleander) leaves. Methods: Cytotoxic activities were evaluated by WST-1 bioassay on two human cancer cell lines, namely human colon adenocarcinoma cell line HT-29 and human breast cancer cell line MDA-MB-231. The antioxidant property of N. oleander extracts was assessed by DPPH scavenging and β-carotene bleaching tests. The agar disc diffusion method was used for the determination of antimicrobial activity against different strains. Results: Using cell viability indices, the WST-1 test revealed that both extracts reduced cell viability in both cell lines. Our results also showed that aqueous extract was more active than ethanolic extract, with IC