Prevalence and genotype distribution of hepatitis B virus among migrant workers in Lombok Island, Indonesia

Laura Yamani; Eva Triani; Mochamad Amin; Mochamad Juniastuti; Mochamad Soetjipto; Mochamad Nasronudin; Hak Hotta; Yoshitake Hayashi; Maria Lusida; Laura Yamani; Laura Yamani; Mochamad Amin; Mochamad Juniastuti; Takako Utsumi; Takako Soetjipto; Takako Nasronudin; Maria Lusida; Eva Triani; Maria Lusida; Takako Utsumi; Yoshihiko Yano

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Prevalence and genotype distribution of hepatitis B virus among migrant workers in Lombok Island, Indonesia

Author: Laura YAMANI ¹ ; Eva TRIANI ¹ ; Mochamad AMIN ¹ ; Mochamad JUNIASTUTI ¹ ; Mochamad SOETJIPTO ¹ ; Mochamad NASRONUDIN ¹ ; Hak HOTTA ¹ ; Yoshitake HAYASHI ¹ ; Maria LUSIDA ¹ ; Laura YAMANI ² ; Laura YAMANI ³ ; Mochamad AMIN ³ ; Mochamad JUNIASTUTI ³ ; Takako UTSUMI ³ ; Takako SOETJIPTO ³ ; Takako NASRONUDIN ³ ; Maria LUSIDA ³ ; Eva TRIANI ⁴ ; Maria LUSIDA ⁵ ; Takako UTSUMI ⁶ ; Yoshihiko YANO ⁶
Author Information

1. Institute of Tropical Disease, Universitas Airlangga
2. Department of Epidemiology, Faculty of Public Health, Universitas Airlangga
3. Indonesia-Japan Collaborative Research, Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Universitas Airlangga
4. Faculty of Medicine, Mataram University
5. Department of Microbiology, Faculty of Medicine, Universitas Airlangga
6. Center for Infectious Diseases, Kobe University Graduate, School of Medicine
Collective Name:Department of Microbiology, Faculty of Medicine, Universitas Airlangga;Department of Biochemistry, Faculty of Medicine, Universitas Airlangga
Publication Type:Journal Article
Keywords: HBV; Indonesia; Migrant workers; Subgenotypes
From: Asian Pacific Journal of Tropical Medicine 2020;13(1):8-16
CountryChina
Language:Chinese
Abstract: To examine the potential risk of hepatitis B virus (HBV) spread in Indonesia by migrant workers, based on the molecular characteristics of HBV strains. Methods: Sera collected from migrant workers traveling to their destination countries (pre-migrant workers) and those returning to Indonesia (post-migrant workers) were screened for HBsAg by ELISA, followed by HBV DNA detection by PCR and (sub) genotype/subtype determination according to surface region and whole genome sequencing. Results: Of 87 pre-migrant workers, 15 (17.24%) were HBsAgpositive, whereas 15 (12.10%) of 124 post-migrant workers were HBsAg seropositive. HBV genotype analysis based on the S region showed that HBV-B3/adw2 was predominant (96.15%, 25/26) whereas 3.85% (1/26) of isolates were HBV-C3/adrq+. Whole genome sequencing of selected strains and phylogenetic tree analysis identified subgenotype B7 in three samples previously categorized as subgenotype B3 based on S region analysis, supporting a recent argument that subgenotypes B5/B7/B8/B9 could be considered as a quasi-subgenotype of B3. Conclusions: A high prevalence of HBsAg carriers was detected among migrant workers from Lombok Island, with no significant difference in prevalence between before and after returning to Indonesia. All strains were classified into genotypes common in Indonesia, and the results suggested that migrant workers are not a risk factor for HBV transmission into Indonesia.