Antimalarial activity of the aqueous extract of Euphorbia cordifolia Elliot in Plasmodium berghei-infected mice
- Author:
Raceline Gounoue KAMKUMO
1
;
Jaures Marius Tsakem NANGAP
1
;
Florence Ngueguim TSOFACK
1
;
Theophile DIMO
1
;
Lauve Rachel Tchokouaha YAMTHE
2
;
Patrick Valere Tsouh FOKOU
3
;
Mariscal Brice Tchatat TALI
3
;
Fabrice Fekam BOYOM
3
Author Information
- Publication Type:Journal Article
- Keywords: Antimalarial activity; Curative effects; Euphorbia cordifolia; Plasmodium berghei
- From: Asian Pacific Journal of Tropical Medicine 2020;13(4):176-184
- CountryChina
- Language:Chinese
- Abstract: Objective: To evaluate the antimalarial activity of the aqueous extract of Euphorbia (E.) cordifolia Elliot against Plasmodium (P.) berghei-infected mice. Methods: Thirty healthy Swiss mice were intraperitoneally inoculated with 200 μL of P. berghei parasitized-erythrocytes and divided into five groups, and then daily treated for 5 d with single dose of 10 mL/kg of distilled water for malaria control, 10 mg/kg of chloroquine for the chloroquine control and 100, 200 and 400 mg/kg of the aqueous extract of E. cordifolia for the three test groups. Parasitaemia was monitored by Giemsa-staining. At the end of the treatment, animals were sacrificed, and blood was collected for haematological and biochemical analyses. Organs were collected for biochemical and histopathological analyses. Statistical significance (P<0.05) was evaluated by analysis of variance followed by the Tukey post-test using Graphpad prism 7.0. Results: E. cordifolia extract decreased the parasite load to 2.46%, with an effective dose (ED
