Genomic characterization of velogenic avian orthoavulavirus 1 isolates from poultry workers: Implications to emergence and its zoonotic potential towards public health
- Author:
Muhammad Zubair SHABBIR
1
;
Masood RABBANI
1
;
Ruth Helmus NISSLY
2
;
Levina LIM
2
;
Shubhada K. CHOTHE
2
;
Murugan SUBBIAH
2
;
Bhushan M JAYARAO
2
;
Suresh V. KUCHIPUDI
2
;
Abdul AHAD
3
;
Aswathy SEBASTIAN
4
;
Istvan ALBERT
4
;
Aziz UL-RAHMAN
5
Author Information
- Publication Type:Journal Article
- Keywords: Avian orthoavulavirus 1; Evolution; Genotype XIII; Human originated strain; Poultry workers; Zoonotic potential
- From: Asian Pacific Journal of Tropical Medicine 2021;14(2):64-72
- CountryChina
- Language:Chinese
- Abstract: Objective: To carry out the genetic characterization and evolutionary analysis of three avian orthoavulavirus 1 (AOAV-1) isolates from poultry workers with respiratory symptoms. Methods: Using Illumina MiSeq, whole-genome sequencing was carried out to assess the evolutionary dynamics of three AOAV-1 isolates. A phylogenetic and comparative analysis of all coding genes was done using bioinformatics tools. Results: Phylogenetic analysis and genetic distance estimation suggested a close relationship among human- and avian-originated velogenic strains of genotype XIII, sub-genotype XIII.2.1. Several substitutions in the significant structural and biological motifs were exclusively identified in the human-originated strains. Conclusions: To our knowledge, this is the first report of a velogenic AOAV-1 isolate from natural infection of the human upper respiratory tract. Our findings highlight the evolution and zoonotic potential of velogenic AOAV-1 in a disease endemic setting.
