Sex differences in SARS-CoV-2 infections, anti-viral immunity and vaccine responses

Author: Abhishek MOHANTY ¹ ; Aanchal SAWHNEY ¹ ; Vandana JAIN ¹ ; Abhishek MOHANTY ² ; Vishal RAO ² ; Shefali GUPTA ³ ; Periyasamy GOVINDARAJ ⁴ ; Sambit MOHANTY ⁵
Author Information

1. Rajiv Gandhi Cancer Institute and Research Centre
2. Hcg Cancer Hospitals
3. All India Institute of Medical Sciences
4. Centre for Dna Finger Printing and Diagnostics
5. Core Diagnostics
Publication Type:Journal Article
Keywords: Antiviral immunity; COVID-19 pandemic; Innate immunity; SARS-CoV-2; Sex based mitochondrial differences; Sex differences; Vaccine responses
From: Asian Pacific Journal of Tropical Medicine 2022;15(3):97-105
CountryChina
Language:Chinese
Abstract: The COVID-19 pandemic has revealed sex-based differences in anti-viral responses, with a higher rate of SARS-CoV-2 infections as well as a higher rate of morbidity and mortality in men than in women. Males and females also show disparate immune responses to COVID-19 infection, which may be important contributors to lower rates of infection, disease severity and deaths in women than in men. Here, the authors review sex differences in SARSCoV- 2 infections, anti-viral immunity and vaccine responses, putting forth the importance of sex, the underappreciated variables in vaccine response and disease infectivity.