Correlation between DNA ploidy, pathological stage and prognosis in renal cell carcinoma.
- Author:
Jang Ki SUH
1
;
Yang Il PARK
Author Information
1. Department of Urology, Chonnam University, Medical School, Kwangju, Korea.
- Publication Type:Original Article
- Keywords:
DNA ploidy;
renal cell carcinoma
- MeSH:
Aneuploidy;
Carcinoma, Renal Cell*;
Diploidy;
DNA*;
Follow-Up Studies;
Humans;
Nephrectomy;
Ploidies*;
Prognosis*;
S Phase
- From:Korean Journal of Urology
1991;32(6):867-872
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The correlation between deoxyribonucleic acid (DNA) ploidy, pathological stage and prognosis was evaluated in 18 patients, who underwent nephrectomy and proved to be renal cell carcinoma. Of them, 10 (56%) cases showed a DNA diploid pattern and 8 (44% ) cases a DNA aneuploid one. The pathologic stage and DNA ploidy. revealed aneuploid tumors in 2(29%) of 7 patients with stage pT1-2N0M0(group 1). in 2 (33%) of 6 patients with stage pT3aN0M0 (group 2) and in 4 (80%) of 5 patients with stage pT3bN02M0.(group 3) respectively. The Mean follow up period was 3.3 years. The number of the survivals more than 2 years were 12(67%). comprising 8 of diploid tumors and 4 of aneuploid tumors, suggesting that patients with diploid tumor survived longer than those with aneuploid tumor. The survivals more than 2 years in relation to pathological stage were 6 (86%) or 7 patients with group 1, 5(83%) of 6 with group 2 and 1 (20%) of 5 with group 3, respectively. The S phase fraction showed no significant difference between diploid and aneuploid tumors, but the survivals more than 2 years had significantly lower S phase fraction than those less than 2 years. The results suggest that DNA ploidy correlates with pathologic stage and prognosis. and S phase fraction may influence the prognosis independently.
