The predictors of long-COVID in the cohort of Turkish Thoracic Society-TURCOVID multicenter registry: One year follow-up results

Serap Argun Baris; Ilknur Basyigit; Hasim Boyaci; Oya Baydar Toprak; Pelin Duru Cetinkaya; Pelin Pinar Deniz; Ismail Hanta; Pelin Duru Cetinkaya; Pelin Pinar Deniz; Fusun Fakili; Nurdan Kokturk; Tansu Ulukavak Ciftci; Ipek Kivilcim Oguzulgen; Seval Kul; Ozgecan Kayalar; Yildiz Tutuncu; Emel Azak; Mutlu Kuluozturk; Pinar Aysert Yildiz; Hasan Selcuk Ozger; Oguz Kilinc; Begum Ergan; Oya Itil; Neslihan Kose; Gulseren Sagcan; Caglar Cuhadaroglu; Hacer Kuzu Okur; Mehtap Hafizoglu; Abdullah Sayiner; Esra Nurlu Temel; Onder Ozturk; Vildan Avkan Oguz; Firat Bayraktar; Ozlem Ataoglu; Merve Ercelik; Pinar Yildiz Gulhan; Aysegul Tomruk Erdem; Muge Tor; Hasan Bayram

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The predictors of long-COVID in the cohort of Turkish Thoracic Society-TURCOVID multicenter registry: One year follow-up results

Author: Serap Argun BARIS ¹ ; Ilknur BASYIGIT ¹ ; Hasim BOYACI ¹ ; Oya Baydar TOPRAK ² ; Pelin Duru CETINKAYA ² ; Pelin Pinar DENIZ ² ; Ismail HANTA ² ; Pelin Duru CETINKAYA ³ ; Pelin Pinar DENIZ ³ ; Fusun FAKILI ⁴ ; Nurdan KOKTURK ⁵ ; Tansu Ulukavak CIFTCI ⁵ ; Ipek Kivilcim OGUZULGEN ⁵ ; Seval KUL ⁶ ; Ozgecan KAYALAR ⁷ ; Yildiz TUTUNCU ⁸ ; Emel AZAK ⁹ ; Mutlu KULUOZTURK ¹⁰ ; Pinar Aysert YILDIZ ¹¹ ; Hasan Selcuk OZGER ¹¹ ; Oguz KILINC ¹² ; Begum ERGAN ¹² ; Oya ITIL ¹² ; Neslihan KOSE ¹³ ; Gulseren SAGCAN ¹⁴ ; Caglar CUHADAROGLU ¹⁴ ; Hacer Kuzu OKUR ¹⁴ ; Mehtap HAFIZOGLU ¹⁵ ; Abdullah SAYINER ¹⁵ ; Esra Nurlu TEMEL ¹⁶ ; Onder OZTURK ¹⁷ ; Vildan Avkan OGUZ ¹⁸ ; Firat BAYRAKTAR ¹⁹ ; Ozlem ATAOGLU ²⁰ ; Merve ERCELIK ²⁰ ; Pinar Yildiz GULHAN ²⁰ ; Aysegul Tomruk ERDEM ²¹ ; Muge TOR ²¹ ; Hasan BAYRAM ²²
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1. Department of Pulmonary Medicine, Faculty of Medicine, Kocaeli University
2. Department of Pulmonary Medicine, Faculty of Medicine, Cukurova University
3. Department of Pulmonary Medicine, University of Health Sciences, Adana City Training and Research Hospital
4. Department of Pulmonary Medicine, Faculty of Medicine, Gaziantep University
5. Department of Pulmonary Medicine, Faculty of Medicine, Gazi University
6. Department of Biostatistics, Faculty of Medicine, Gaziantep University
7. Koc University Research Center for Translational Medicine (KUTTAM), Koc University School of Medicine
8. Department of Immunology, Koc University Research Center for Translational Medicine (KUTTAM), Koc University School of Medicine
9. Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Kocaeli University
10. Department of Pulmonary Medicine, Faculty of Medicine, Firat University
11. Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Gazi University
12. Department of Pulmonary Medicine, Faculty of Medicine, Dokuz Eylul University
13. Department of Pulmonary Medicine, Bilecik Training and Research Hospital
14. Department of Pulmonary Medicine, Altunizade Acibadem Hospital
15. Department of Pulmonary Medicine, Faculty of Medicine, Ege University
16. Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Suleyman Demirel University
17. Department of Pulmonary Medicine, Faculty of Medicine, Suleyman Demirel University
18. Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Dokuz Eylul University
19. Department of Internal Medicine, Faculty of Medicine, Dokuz Eylul University
20. Department of Pulmonary Medicine, Faculty of Medicine, Duzce University
21. Department of Pulmonary Medicine, Faculty of Medicine, Zonguldak Bulent Ecevit University
22. Department of Pulmonary Medicine, Koc University Research Center for Translational Medicine (KUTTAM), Koc University School of Medicine
Publication Type:Journal Article
Keywords: Comorbidity; Dyspnea; Fatigue; Long COVID-19
From: Asian Pacific Journal of Tropical Medicine 2022;15(9):400-409
CountryChina
Language:Chinese
Abstract: Objective: To evaluate long-term effects of COVID-19, and to determine the risk factors in long-COVID in a cohort of the Turkish Thoracic Society (TTS)-TURCOVID multicenter registry. Methods: Thirteen centers participated with 831 patients; 504 patients were enrolled after exclusions. The study was designed in three-steps: (1) Phone questionnaire; (2) retrospective evaluation of the medical records; (3) face-to-face visit. Results: In the first step, 93.5% of the patients were hospitalized; 61.7% had a history of pneumonia at the time of diagnosis. A total of 27.1% reported clinical symptoms at the end of the first year. Dyspnea (17.00%), fatigue (6.30%), and weakness (5.00%) were the most prevalent long-term symptoms. The incidence of long-term symptoms was increased by 2.91 fold (95% CI 1.04-8.13, P=0.041) in the presence of chronic obstructive pulmonary disease and by 1.84 fold (95% CI 1.10-3.10, P=0.021) in the presence of pneumonia at initial diagnosis, 3.92 fold (95% Cl 2.29-6.72, P=0.001) of dyspnea and 1.69 fold (95% Cl 1.02-2.80, P=0.040) fatigue persists in the early-post-treatment period and 2.88 fold (95% Cl 1.52-5.46, P=0.001) in the presence of emergency service admission in the post COVID period. In step 2, retrospective analysis of 231 patients revealed that 1.4% of the chest X-rays had not significantly improved at the end of the first year, while computed tomography (CT) scan detected fibrosis in 3.4%. In step 3, 138 (27.4%) patients admitted to face-to-face visit at the end of first year; at least one symptom persisted in 49.27% patients. The most common symptoms were dyspnea (27.60%), psychiatric symptoms (18.10%), and fatigue (17.40%). Thorax CT revealed fibrosis in 2.4% patients. Conclusions: COVID-19 symptoms can last for extended lengths of time, and severity of the disease as well as the presence of comorbidities might contribute to increased risk. Long-term clinical issues should be regularly evaluated after COVID-19.