In vivo sedative and muscle relaxants activity of Diospyros lotus L
10.1016/S2221-1691(15)30345-2
- Author:
Abdur RAUF
1
;
Ghias UDDIN
1
;
Bina Shaheen SIDDIQUI
2
;
Haroon KHAN
3
Author Information
1. Institute of Chemical Sciences, University of Peshawar
2. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi
3. Department of Pharmacy, Abdul Wali Khan University
- Publication Type:Journal Article
- Keywords:
Diospyros lotus;
Ebenaceae;
Muscle relaxants activity;
Sedative
- From:Asian Pacific Journal of Tropical Biomedicine
2015;5(4):277-280
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To evaluate the sedative effect of Diospyros lotus L (D. lotus) extract in mice using the open field and Rota rod tests. METHODS: For the sedative and muscle relaxants activities of extract/fractions of the plant, in-vivo open field and phenobarbitone-induced sleeping time were used, while the Roda rod test was employed in animals for the assessment of muscle relaxant activity. RESULTS: Results from this investigation revealed that the extracts of D. lotus have exhibited significant sedative effect in mice (45.98%) at 100 mg/kg i.p. When the extract was partitioned with different solvents, the n-hexane fraction was inactive whereas the chloroform fraction was the most active with 82.67% sedative effect at 50 and 100 mg/kg i.p. On the other hand, the ethyl acetate and n-butanol fractions displayed significant sedative effects (55.65% and 40.87%, respectively) at 100 mg/kg i.p. Among the tested extract/fractions, only chloroform and ethyl acetate fractions showed significant (P < 0.05) muscle relaxant activity in the Rota rod test. CONCLUSIONS: In short, our study provided scientific background to the traditional uses of D. lotus as sedative.
