Anti-malarial effect of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one and green tea extract on erythrocyte-stage Plasmodium berghei in mice
10.1016/j.apjtb.2015.07.021
- Author:
Phitsinee THIPUBON
1
;
Somdet SRICHAIRATANAKOOL
1
;
Wachiraporn TIPSUWAN
2
;
Chairat UTHAIPIBULL
3
;
Sineenart SANTITHERAKUL
4
Author Information
1. Department of Biochemistry, Faculty of Medicine, Chiang Mai University
2. Division of Biochemistry, School of Medical Sciences, University of Phayao
3. National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA)
4. Medical Science Research Equipment Center, Faculty of Medicine, Chiang Mai University
- Publication Type:Journal Article
- Keywords:
Antimalarial drug;
Green tea;
Hydroxypyridinone;
Iron chelator;
Plasmodium
- From:Asian Pacific Journal of Tropical Biomedicine
2015;5(11):932-936
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To examine the efficacy of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) iron chelator and green tea extract (GTE) as anti-malarial activity in Plasmodium berghei ( P. berghei) infected mice. Methods: The CM1 (0-100 mg/kg/day) and GTE (0-100 mg (-)-epigallocatechin 3-gallate equivalent/kg/day) were orally administered to P. berghei infected mice for consecutive 4 days. Parasitized red blood cells (PRBC) were enumerated by using Giemsa staining microscopic method. Results: CM1 lowered percentage of PRBC in dose-dependent manner with an ED
