Inhibitory effect of Thymus vulgaris extract on memory impairment induced by scopolamine in rat
10.1016/j.apjtb.2015.07.006
- Author:
Zahra RABIEI
1
;
Shiva MOKHTARI
1
;
Samira ASGHARZADE
1
;
Samira RAHNAMA
1
;
Mahmoud RAFIEIAN-KOPAEI
1
;
Samira ASGHARZADE
2
;
Mostafa GHOLAMI
3
Author Information
1. Medical Plants Research Center, Shahrekord University of Medical Sciences
2. Department of Molecular Medicine, Faculty of Advanced Medical Technologies, Tehran University of Medical Sciences
3. Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences
- Publication Type:Journal Article
- Keywords:
Acetylcholinesterase inhibitors;
Memory and learning;
Scopolamine;
Thymus vulgaris
- From:Asian Pacific Journal of Tropical Biomedicine
2015;5(10):845-851
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of Thymus vulgaris (. T. vulgaris) on learning and memory functions in scopolamine-induced memory deficit in rats. Memory enhancing activity in scopolamine-induced amnesic rats was investigated by assessing the Morris water maze and passive avoidance paradigm. Methods: A total of 42 male Wistar rats were divided into 6 equal groups as follow: control group: received water, scopolamine treated group: received scopolamine 1 mg/kg for 15 days, two scopolamine + T. vulgaris treated groups: received scopolamine and T. vulgaris extract 50 and 100 mg/kg body weight per day for 15 days, two intact groups: received T. vulgaris extract 50 and 100 mg/kg body weight per day for 15 days. Results: Administration of T. vulgaris extract significantly restored memory and learning impairments induced by scopolamine in the passive avoidance test and Morris water maze test. Conclusions: T. vulgaris extract has repairing effects on memory and behavioral disorders produced by scopolamine and may have beneficial effects in the treatment of Alzheimer's disease.
