Effects of Matricaria chamomilla extract on motor coordination impairment induced by scopolamine in rats
10.1016/j.apjtb.2015.06.006
- Author:
Samira ASGHARZADE
1
;
Zahra RABIEI
1
;
Mahmoud RAFIEIAN-KOPAEI
1
;
Samira ASGHARZADE
2
Author Information
1. Medical Plants Research Center, Shahrekord University of Medical Sciences
2. Department of Molecular Medicine, Faculty of Advanced Medical Technologies, Tehran University of Medical Sciences
- Publication Type:Journal Article
- Keywords:
Chamomile plant;
Motor coordination impairment;
Rat;
Scopolamine
- From:Asian Pacific Journal of Tropical Biomedicine
2015;5(10):829-833
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the effect of ethanolic extract of chamomile on balance and motor learning in rats receiving scopolamine and intact rats. Methods: Fourty-two rats were divided into 6 groups ( n = 7). Control group received distilled water. Rats in Group 2 were given 1 mg/kg scopolamine. Groups 3 and 4 received chamomile extract 200 mg/kg and 500 mg/kg, respectively, and scopolamine simultaneously for 20 days. Intact groups (Groups 5 and 6) only received chamomile extract 200 mg/kg and 500 mg/kg, respectively. Motor coordination of rats was assessed with rotarod apparatus. Results: According to the obtained results, compared with the control group, scopolamine significantly decreased time spent on rotarod performance (. P < 0.001). Compared with scopolamine group, the strength and staying on rotarod apparatus in Group 3 significantly increased ( P < 0.05). The results of this research showed that intact groups that received only chamomile extract at doses of 200 mg/kg and 500 mg/kg significantly increased time spent on rotarod, compared with scopolamine group ( P < 0.001). Conclusions: The results of this study indicated the high antioxidant property and protective effect of chamomile extract on motor coordination in the groups that received scopolamine.
