Antibacterial activities of ethanol extracts of Philippine medicinal plants against multidrug-resistant bacteria
10.1016/j.apjtb.2015.04.005
- Author:
Demetrio L. VALLE
1
;
Juliana Janet M. PUZON
1
;
Windell L. RIVERA
1
;
Demetrio L. VALLE
2
;
Jeannie I. ANDRADE
2
;
Juliana Janet M. PUZON
3
;
Windell L. RIVERA
3
;
Esperanza C. CABRERA
4
Author Information
1. Institute of Biology, College of Science, University of the Philippines
2. Makati Medical Center
3. Natural Sciences Research Institute, University of the Philippines
4. Biology Department, De La Salle University
- Publication Type:Journal Article
- Keywords:
Ehretia microphylla;
Multidrug-resistant bacteria;
Philippine herbal medicine;
Phyllanthus niruri;
Piper betle;
Psidium guajava
- From:Asian Pacific Journal of Tropical Biomedicine
2015;5(7):532-540
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the antibacterial activities of crude ethanol extracts of 12 Philippine medicinal plants. Methods: Crude ethanol extracts from 12 Philippine medicinal plants were evaluated for their antibacterial activity against methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, extended spectrum β-lactamase-producing, carbapenem-resistant Enterobacteriaceae and metallo-β-lactamase-producing Pseudomonas aeruginosa and Acinetobacter baumannii. Results: The leaf extracts of Psidium guajava, Phyllanthus niruri, Ehretia microphylla and Piper betle (P. betle) showed antibacterial activity against the Gram-positive methicillin- resistant Staphylococcus aureus and vancomycin-resistant Enterococcus. P. betle showed the highest antibacterial activity for these bacteria in the disk diffusion (16-33 mm inhibition diameter), minimum inhibitory concentration (19-156 μg/mL) and minimum bactericidal concentration (312 μg/mL) assays. P. betle leaf extracts only showed remarkable antibacterial activity for all the Gram-negative multidrug-resistant bacteria (extended spectrum β-lactamase-producing, carbapenem-resistant Enterobacteriaceae and metallo-c-lactamase-producing) in the disk diffusion (17-21 mm inhibition diameter), minimum inhibitory concentration (312-625 μg/mL) and minimum bactericidal concentration (312-625 μg/mL) assays. Conclusions: P. betle had the greatest potential value against both Gram-negative and Gram-positive multidrug-resistant bacteria. Favorable antagonistic activities were also exhibited by the ethanol extracts of Psidium guajava, Phyllanthus niruri and Ehretia microphylla.
