Effect of pre-existing Schistosoma haematobium infection on Plasmodium berghei multiplications in imprinting control region mice
10.1016/j.apjtb.2015.03.007
- Author:
Benjamin AMOANI
1
;
Elvis Ofori AMEYAW
1
;
Du-Bois ASANTE
1
;
Francis Ackah ARMAH
1
;
Collins Paa KWESI BOTCHEY
1
;
Johnson Nyarko BOAMPONG
1
;
Benjamin AMOANI
2
;
James PRAH
3
Author Information
1. Department of Biomedical and Forensic Sciences, University of Cape Coast
2. Noguchi Memorial Institute for Medical Research, University of Ghana
3. University of Cape Coast Hospital
- Publication Type:Journal Article
- Keywords:
Parasitaemia;
Plasmodium berghei;
Schistosoma haematobium;
Survivability
- From:Asian Pacific Journal of Tropical Biomedicine
2015;5(6):488-492
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of pre-existing Schistosoma haematobium (S. haematobium) infection on malaria disease severity. Methods: The study involved the use of twenty-five imprinting control region mice, fifteen of which were initially infected with S. haematobium. Five of the remaining ten schisto-uninfected mice together with five schisto-infected mice were infected with Plasmodium berghei (P. berghei) after four weeks (acute stage) of schistosoma infection. The remaining five schisto-uninfected mice together with five schisto-infected mice were also infected with P. berghei after seven weeks (chronic stage) of schistosoma infection. The last five schisto-infected mice were used as control group. They were then monitored for changes in P. berghei parasitaemia on Days 3, 5, 7, 9 and 11 post-infection. Records on their survivability were also taken. Results: The co-infected mice had significantly higher malaria parasitaemia, compared with the mono-infected mice during acute S. haematobium infection. In contrast, the coinfected mice had significantly lower malaria parasitaemia during chronic S. haematobium infection and a higher survival rate. Conclusions: Co-infection of mice with P. berghei during acute S. haematobium infection resulted in rapid P. berghei development and increased malaria parasitaemia. However, the co-infection resulted in slower P. berghei development and decreased malaria parasitaemia with enhanced survivability of the mice during chronic S. haematobium infection. Therefore, pre-existing chronic S. haematobium infection may provide some protection to the host by reducing parasitaemia.
