Exposure to polycyclic aromatic hydrocarbons with special focus on cancer
10.1016/S2221-1691(15)30003-4
- Author:
Thamaraiselvan RENGARAJAN
1
;
Thamaraiselvan RENGARAJAN
2
;
Peramaiyan RAJENDRAN
2
;
Ikuo NISHIGAKI
2
;
Natarajan NANDAKUMAR
3
;
Boopathy LOKESHKUMAR
4
;
Palaniswami RAJENDRAN
5
Author Information
1. Department of Chemical Pathology, School of medical Sciences, Universiti Sains Malaysia
2. NPO-International Laboratory of Biochemistry
3. Department of Microbiology, Immunology and Genetics, Ben Gurion University of the Negev
4. Department of Pharmacology and Environmental Toxicology, Dr. ALM PG IBMS, University of Madras
5. Department of Applied Zoology and Biotechnology, Vivekananda College, Affiliated to Madurai Kamaraj University
- Publication Type:Journal Article
- Keywords:
Benzo(a)pyrene;
Cancer;
DMBA;
Environmental pollution;
PAH
- From:Asian Pacific Journal of Tropical Biomedicine
2015;5(3):182-189
- CountryChina
- Language:Chinese
-
Abstract:
Polycyclic aromatic hydrocarbons (PAHs) are a group of compounds consisting of two or more fused aromatic rings. Most of them are formed during incomplete combustion of organic materials such as wood and fossil fuels, petroleum products, and coal. The composition of PAH mixtures varies with the source and is also affected by selective weathering effects in the environment. PAHs are ubiquitous pollutants frequently found in a variety of environments such as fresh water and marine sediments, the atmosphere, and ice. Due to their widespread distribution, the environmental pollution due to PAHs has aroused global concern. Many PAHs and their epoxides are highly toxic, mutagenic and/or carcinogenic to microorganisms as well as to higher forms of life including humans. The main aim of this review is to provide contemporary information on PAH sources, route of exposure, worldwide emission rate, and adverse effects on humans, especially with reference to cancer.
