Antidiabetic and antidiarrhoeal effects on ethanolic extract of Psidium guajava (L.) Bat. leaves in Wister rats
10.1016/S2221-1691(15)30163-5
- Author:
Santosh MAZUMDAR
1
;
Rasheda AKTER
1
;
Debashish TALUKDER
2
Author Information
1. Pharmacology research division, Bangladesh Council of Scientific and Industrial Research Laboratories Chittagong
2. Applied Zoology Research Division, Bangladesh Council of Scientific and Industrial Research Laboratories
- Publication Type:Journal Article
- Keywords:
Antidiabetic;
Antidiarrhoea;
Leave extract;
Psidium guajava;
Wister rats
- From:Asian Pacific Journal of Tropical Biomedicine
2015;5(1):10-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the antidiabetic and the antidiarrhoeal effects of ethanolic extracts of Psidium guajava leave (EEPGL) in Wister rats to support its traditional uses. Methods: Oral glucose tolerance test model and alloxan induced diabetic test model were performed to evaluate antidiabetic activity of EEPGL at doses of 1.00, 0.50 and 0.75 g/kg respectively. For antidiarrhoeal effects of EEPGL, castor oil-induced diarrhoea model and gastrointestinal motility test with barium sulphate milk model were also assessed at doses of 750, 500 and 250 mg/kg, respectively. Results: Administration of EEPGL at doses 1.00 and 0.50 g/kg significantly (P<0.05) decreased blood glucose levels in oral glucose tolerance test model as well as 0.75 g/kg dose in alloxan induced diabetic test model in Wister rats (P<0.001). Application of EEPGL at doses of 750 and 500 mg/kg showed antidiarrhoeal effect in castor oil-induced diarrhoeal model (P<0.001 and P<0.01, respectively), and 750 mg/kg (P<0.01), 500 and 250 mg/kg (P<0.05) doses in barium sulphate milk model in aforesaid animals. Conclusions: These results exhibited the significant antidiabetic and antidiarrhoeal activities of ethanolic extracts of Psidium guajava leave in Wister rats
