Anti-breast cancer properties and toxicity of Dillenia suffruticosa root aqueous extract in BALB/c mice
10.1016/j.apjtb.2015.09.008
- Author:
Latifah Saiful YAZAN
1
;
Yong Sze ONG
1
;
Jhi Biau FOO
1
;
Yin Sim TOR
1
;
Latifah Saiful YAZAN
2
;
Nur Elena ZAABA
2
;
Razana Mohd ALI
3
Author Information
1. Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, UPM Sedang
2. Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang
3. Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang
- Publication Type:Journal Article
- Keywords:
4T1 Tumor-bearing mice;
Breast cancer;
Dillenia suffruticosa;
Toxicity
- From:Asian Pacific Journal of Tropical Biomedicine
2015;5(12):1018-1026
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To determine the anti-breast cancer activities and the safety oral consumption of Dillenia suffruticosa root aqueous extract (DRAE) in BALB/c mice. Methods: In the anti-breast cancer study, female BALB/c mice were divided into five groups (n = 12), which were (1) positive control (with breast cancer, untreated), (2) negative control (without breast cancer, untreated) and other three groups of mice with breast cancer treated with 1000, 500 and 250 mg/kg of DRAE, respectively, by oral gavage for 28 days. All mice except from the negative control group were injected into the mammary fat pad with 4T1 cells (1 × 10
