Bee pollen extract of Malaysian stingless bee enhances the effect of cisplatin on breast cancer cell lines
10.1016/j.apjtb.2015.12.011
- Author:
Wan Adnan WAN OMAR
1
;
Nur Asna AZHAR
1
;
Nurdianah Harif FADZILAH
1
;
Nik Nur Syazni NIK MOHAMED KAMAL
1
Author Information
1. Advanced Medical and Dental Institute, Universiti Sains Malaysia
- Publication Type:Journal Article
- Keywords:
Antioxidant;
Antiproliferative activity;
Bee pollen extract;
Malaysian stingless bee;
Synergistic effect
- From:Asian Pacific Journal of Tropical Biomedicine
2016;6(3):265-269
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the antioxidant and antiproliferative effect of methanolic bee pollen extract (BPE) of Malaysian stingless bee [Lepidotrigona terminata (L. terminata)] and its synergistic effect with cisplatin (a chemotherapeutic drug) on MCF-7 cancer cell line. Methods: The antioxidant activity of BPE from L. terminata was measured by using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) assay. Antiproliferative activity at different concentrations of BPE and cisplatin was determined through using MTT assay on MCF-7 and L929 cell lines. An interaction effect (synergistic, additive and antagonistic) between BPE and cisplatin was determined by CompuSyn software based on MTT assay data. Results: The EC
