Pharmacological effects of ethanol extract of Egyptian Artemisia herba-alba in rats and mice
10.1016/j.apjtb.2015.10.005
- Author:
Gehad Abdel Raheem ABDEL JALEEL
1
;
Heba Mohammed Ibrahim ABDALLAH
1
;
Nawal E.L. Sayed GOMAA
1
Author Information
1. Pharmacology Department, National Research Centre
- Publication Type:Journal Article
- Keywords:
Antioxidant;
Artemisia herba-alba;
Gastric ulcer;
Inflammation;
Mice;
Rats
- From:Asian Pacific Journal of Tropical Biomedicine
2016;6(1):44-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate some pharmacological effects including gastroprotective, anti-inflammatory, analgesic, antipyretic and in vitro antioxidant effects of Artemisia herba-alba extract in different experimental models. Methods: Inflammation was induced in rat paw by subcutaneous injection of 1% (v/v) carrageenan solution. Writhes was induced in mice by intraperitoneal injection of 0.6% (v/v) acetic acid solution. Pyrexia was induced using Brewer's yeast suspension. Gastric lesion was induced in rats by oral administration of 99% ethanol. The anti-inflammatory, analgesic, antipyretic and gastroprotective activities of Artemisia herba-alba extract were investigated respectively. In vitro antioxidant effect was investigated using DPPH free radical. Results: The plant extract showed anti-inflammatory effect in carrageenan-induced paw edema in rats, analgesic effect against acetic acid-induced writhing, and antipyretic activity in Brewer's yeast model of pyrexia. Besides, it was shown to be a gastroprotective agent against ethanol-induced gastric ulcers. The plant also exhibited a free radical scavenging potential in an in vitro antioxidant study using DPPH. Conclusions: The results validate the use of the investigated plant in traditional medicine for different ailments.
