The effects of glycyrrhizic acid and glabridin in the regulation of CXCL5 inflammation gene on acceleration of wound healing
10.1016/j.apjtb.2015.10.009
- Author:
Hong Yung YIP
1
;
Melissa Su Wei POH
1
;
Yoke Yin CHIA
1
Author Information
1. School of Biosciences, Division of Medicine, Pharmacy and Health Sciences, Taylor's University
- Publication Type:Journal Article
- Keywords:
Cell migration;
Cell proliferation;
CXCL5;
Glabridin;
Glycyrrhizic acid;
Inflammation;
Wound healing
- From:Asian Pacific Journal of Tropical Biomedicine
2016;6(2):108-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the anti-inflammatory property of both glycyrrhizic acid (GA) and glabridin in reducing inflammation to accelerate wound regeneration on 3T3-L1 and NIH-3T3 fibroblast cell lines. Methods: Cell proliferation and viability assay (MTT assay), scratch wound healing assays, and quantitative real-time PCR were conducted to investigate the effects on cell proliferation, cell migration, and expression of CXC chemokine ligand 5 inflammation gene respectively. Results: Results showed that at a low concentration of 1 × 10
