A Study of Clinical Characteristics of Cryptococcal Meningitis: Diagnosis and Treatment in 38 cases.
- Author:
Jeong Yeon KIM
1
;
Joon Hong LEE
;
Seung Han SUK
;
Kyoon HUH
Author Information
1. Department of Neurology, College of Medicine, Yonsei University, Korea.
- Publication Type:Original Article
- MeSH:
Amphotericin B;
Diagnosis*;
Fever;
Fluconazole;
Headache;
Humans;
Meningitis, Cryptococcal*;
Nausea;
Neuroimaging;
Seizures;
Vomiting
- From:Journal of the Korean Neurological Association
1995;13(2):298-304
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A clinical analysis was carried out in 38 patients with cryptococcal meningitis who were admitted at Severance hospital from January 1983 to June 1993. Age of patients ranged from 3 to 72 years (mean 37.5). The number of patients with underlying disease were 19(50%), which are equal to the number of patients without associated disease. The major presenting symptoms were headache in 36 patients (95%), fever in 26 patients(68%), nausea and vomiting in 20 patients(53%) in that order. The brain imaging findings were abnormal in 21 patients(57%). The antifungal therapy was done; amphotericin B only in 3 patients; amphotericin B and flucytocine in 23 patients; fluconazole only in 5 patients. The therapeutic responses were good in 19 patients(50%). The patients with favorable outcome were younger less having focal deficit, seizure, or associated disease.
