Comparative investigation of the free radical scavenging potential and anticancer property of Diospyros blancoi (Ebenaceae)
10.1016/j.apjtb.2016.03.004
- Author:
Muhammad Ali KHAN
1
;
Md. Mahbubur RAHMAN
2
;
Md. Nazmul SARDAR
2
;
Md. Saiful Islam ARMAN
2
;
Mamunur RASHID
2
;
Golam SADIK
2
;
A.H.M. Khurshid ALAM
2
;
Md. Badrul ISLAM
3
;
Md. Jahangir Alam KHANDAKAR
4
;
A.H.M. Khurshid ALAM
5
Author Information
1. Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University
2. Department of Pharmacy, University of Rajshahi
3. Drugs and Toxins Research Division, Bangladesh Council of Scientific and Industrial Research
4. Product Development and Validation Department, Square Pharmaceutical Limited
5. Laboratory of Genetics, Graduate School of Biostudies, Kyoto University
- Publication Type:Journal Article
- Keywords:
Anticancer;
Antioxidant;
Cytotoxicity;
Diospyros blancoi;
Free radicals;
Polyphenols
- From:Asian Pacific Journal of Tropical Biomedicine
2016;6(5):410-417
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the comparative effects of Diospyros blancoi (Ebenaceae) leaves (DBL), root bark (DBRB) and stem bark (DBSB) on free radicals and cancer. Methods: The polyphenol contents, antioxidant and free radical scavenging properties were determined using standard spectrophotometric methods. Cytotoxicity and anticancer activities were performed on brine shrimp nauplii and Ehrlich ascite carcinoma cells, respectively. Results: Among the extracts, DBSB showed the highest total antioxidant capacity and reducing capacity on ferrous ion. Based on 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radical scavenging activities, DBSB showed (95.760 ± 0.343)% and (67.460 ± 2.641)% scavenging with IC
