Potential drug-drug interactions in pediatric wards of Gondar University Hospital, Ethiopia: A cross sectional study
10.1016/j.apjtb.2016.04.002
- Author:
Henok GETACHEW
1
;
Mohammed ASSEN
1
;
Akshaya Srikanth BHAGAVATHULA
1
;
Feser DULA
2
Author Information
1. Department of Clinical Pharmacy, School of Pharmacy, College of Medical and Health Science, University of Gondar
2. Department of Hospital Pharmacy, Drug Information Center and Clinical Pharmacy Unit, Gondar University Hospital
- Publication Type:Journal Article
- Keywords:
Ethiopia;
Pediatric ward;
Potential drug-drug interaction;
Prevalence
- From:Asian Pacific Journal of Tropical Biomedicine
2016;6(6):534-538
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To determine the prevalence, level of severity of potential drug-drug interactions (PDDIs) and the associated factors for PDDIs in hospitalized pediatric patients of Gondar University Hospital. Methods: A retrospective cross-sectional study was conducted for a period of 3 months from March to May 2014 in pediatric wards of Gondar University Hospital. Systematic random sampling technique was used to select charts from all pediatric patients' charts with every 7th interval to get sample size of 384. Univariate and multivariate analysis were performed to compute crude odds ratio and adjusted odds ratio respectively. Statistical significance was set at P value < 0.05. Results: A total of 176 (45.8%) patients had at least one PDDI. A total of 393 PDDIs, which were comprised of 283 types of interacting combinations, were identified. Of the total of 393 PDDIs, most were of moderate severity [201 (51%)] followed by minor [152 (39%)] and major severity [40 (10%)]. The most common interacting pairs of major severity were gentamicin + furosemide (6), cotrimoxazole + methotrexate (4) and phenytoin + artemether (4). The occurrence of PDDIs was significantly associated with age and polypharmacy. Conclusions: The study showed that most of the interactions had moderate severity followed by minor severity. Age and polypharmacy were found to show statistically significant association with the occurrence of PDDIs. Due to sensitive nature of pediatrics population, close monitoring is recommended for the detection and management of PDDIs to prevent its negative consequences.
