In vivo assessment of the toxic potential of Dissotis rotundifolia whole plant extract in Sprague–Dawley rats
10.1016/j.apjtb.2016.04.010
- Author:
Charles ANSAH
1
;
Michael Buenor ADINORTEY
2
;
Jerry ASIEDU-LARBI
3
;
Benjamin ABOAGYE
4
;
Du-Bois ASANTE
4
;
Alexander Kwadwo NYARKO
5
Author Information
1. Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology
2. Department of Biochemistry, School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast
3. Pharmacology Unit, Centre for Plant Medicine Research
4. Department of Biomedical and Forensic Sciences, School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast
5. Department of Clinical Pathology, Noguchi Memorial Institute for Medical Research, University of Ghana
- Publication Type:Journal Article
- Keywords:
Dissotis rotundifolia;
Ghana;
Melastomataceae;
Toxic potential
- From:Asian Pacific Journal of Tropical Biomedicine
2016;6(7):574-579
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the toxic potential of Dissotis rotundifolia (D. rotundifolia) whole plant extract in Spraque–Dawley rats within a 2-week period of administration. Methods Methanolic extract of D. rotundifolia was administered orally once daily at dose levels of 0, 100, 300 and 1 000 mg/kg body weight for 14 days. Toxicity was assessed using mortality, clinical signs, body and organ weights, hematological indices, serum chemistry parameters and histopathological analyses. Results There were no treatment-related mortalities or differences in clinical signs, hematology and serum biochemistry. This was confirmed by micrographs obtained from histopathological analysis. Conclusions The results obtained from the sub-acute toxicological assessment of D. rotundifolia extract suggest that the extract is non-toxic at doses up to 1 000 mg/kg/day administered for a period of 14 days.
