Anticancer effects of saponin and saponin–phospholipid complex of Panax notoginseng grown in Vietnam
10.1016/j.apjtb.2016.04.013
- Author:
Thu DANG KIM
1
;
Tung BUI THANH
1
;
Hai NGUYEN THANH
2
;
Duong NGUYEN THUY
3
;
Loi VU DUC
4
;
Thu VU THI
5
;
Thu VU THI
6
;
Hung VU MANH
7
;
Patcharee BOONSIRI
8
Author Information
1. Department of Pharmacology and Clinical Pharmacy, School of Medicine and Pharmacy, Vietnam National University
2. Department of Pharmaceutics and Pharmaceutical Technology, School of Medicine and Pharmacy, Vietnam National University
3. Department of Pharmacology, Hanoi University of Pharmacy
4. Department of Pharmacognosy and Traditional Pharmacy, School of Medicine and Pharmacy, Vietnam National University
5. Faculty of Biology, VNU University of Science
6. Key Laboratory of Enzyme and Protein Technology, VNU University of Science
7. Department of Pharmacology, School of Pharmacy, Lac Hong University
8. Department of Biochemistry, Faculty of Medicine, Khon Kaen University
- Publication Type:Journal Article
- Keywords:
Antitumor;
Breast cancer;
Panax notoginseng;
Saponin;
Saponin–phospholipid complex
- From:Asian Pacific Journal of Tropical Biomedicine
2016;6(9):795-800
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the antitumor activity both in vitro and in vivo of saponin–phospholipid complex of Panax notoginseng. Methods The in vitro cytotoxic effect of saponins extract and saponin–phospholipid complex against human lung cancer NCI-H460 and breast cancer cell lines BT474 was examined using MTS assay. For in vivo evaluation of antitumor potential, saponin and saponin–phospholipid complex were administered orally in rats induced mammary carcinogenesis by 7,12-dimethylbenz(a)anthracene, for 30 days. Results Our data showed that saponin–phospholipid complex had stronger anticancer effect compared to saponin extract. The IC50 values of saponin–phospholipid complex and saponin extract for NCI-H460 cell lines were 28.47 μg/mL and 47.97 μg/mL, respectively and these values for BT474 cells were 53.18 μg/mL and 86.24 μg/mL, respectively. In vivo experiments, administration of saponin, saponin–phospholipid complex and paclitaxel (positive control) effectively suppressed 7,12-dimethylbenz(a) anthracene-induced breast cancer evidenced by a decrease in tumor volume, the reduction of lipid peroxidation level and increase in the body weight, and elevated the enzymatic antioxidant activities of superoxide dismutase, catalase, glutathione peroxidase in rat breast tissue. Conclusions Our study suggests that saponin extract from Panax notoginseng and saponin–phospholipid complex have potential to prevent cancer, especially breast cancer.
