Leonurus sibiricus L. (honeyweed): A review of its phytochemistry and pharmacology
10.1016/j.apjtb.2016.10.003
- Author:
Md. Abu SAYED
1
;
Md. Abu SAYED
2
;
Md. Ashraful ALAM
3
;
Md. Shariful ISLAM
4
;
Abu Zaffar SHIBLY
4
;
Md. Taif ALI
5
;
Md. Emdad ULLAH
5
;
Md. Aslam ALI
6
;
Md. Mahdi HASAN-OLIVE
7
Author Information
1. The United Graduate School of Agricultural Sciences, Iwate University
2. Department of Biochemistry and Molecular Biology, Hajee Mohammad Danesh Science and Technology University
3. Faculty of Engineering, Iwate University
4. Department of Biotechnology and Genetic Engineering, Faculty of Life Science, Mawlana Bhashani Science and Technology University
5. Department of Biochemistry and Molecular Biology, University of Dhaka
6. Key Laboratory of Dairy Science, College of Food Science, Northeast Agricultural University
7. Department of Biomedicine, University of Bergen
- Publication Type:Journal Article
- Keywords:
Allelopathy;
Antidiabetic;
Antioxidant;
Cardiovascular disease;
Leonurus sibiricus
- From:Asian Pacific Journal of Tropical Biomedicine
2016;6(12):1076-1080
- CountryChina
- Language:Chinese
-
Abstract:
Leonurus sibiricus is a herbaceous plant found in many countries in Asia and America. This plant is widely practiced as a remedy for the treatment of diabetes, menstrual irregularities, and bronchitis. The approval of therapeutic implications of any drugs depends on the well characterized mode of actions of the compounds. The bioactive compounds like diterpenes, triterpenes, flavonoids and phenolic acids in Leonurus sibiricus show analgesic, anti-inflammatory, anti-oxidant, anti-atherogenic and anti-hemorrhagic, anti-diabetic, anti-bacterial and allelopathic potency. Interestingly, the expression level of some genes is altered by the crude extract treatments, which are effective against cancers, diabetes and cardiovascular diseases where the molecular mechanisms are yet to be explored. Intriguingly, the extracts significantly induce nitric oxide production by endothelial nitric oxide synthase, a signaling molecule of vasodilation in combination with interferon-γ indicating positive effect on atherosclerosis. Further investigations are required to unlock the effects of bioactive compounds found in extracts at clinical settings.
