Methimazole-Induced Acute Cholestatic Hepatitis in a Patient with History of Simvastatin-Induced Liver Injury.
- Author:
Mi Kyung KWAK
1
;
So Ra KIM
;
Jung Wan PARK
;
Su Jung HAN
;
Min Jin KIM
;
So Young JIN
;
Hye Jeong KIM
;
Jae Young JANG
;
Dong Won BYUN
;
Hyeong Kyu PARK
Author Information
1. Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea. hkpark@schmc.ac.kr
- Publication Type:Case Report
- Keywords:
Methimazole;
Simvastatin;
Drug-induced liver injury;
Drug interactions
- MeSH:
Drug Interactions;
Drug-Induced Liver Injury;
Female;
Hepatitis*;
Humans;
Hyperthyroidism;
Liver*;
Methimazole;
Middle Aged;
Simvastatin
- From:Soonchunhyang Medical Science
2014;20(2):163-167
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Methimazole and prophylthiouracil are commonly prescribed for patients with hyperthyroidism. The serious side effect of toxic hepatitis caused by these two drugs is well known. According to recent Korean and American management guidelines for hyperthyroidism, mehimazole is recommended as the first-choice antithyroid drug for the treatment of hyperthyroidism. Toxic hepatitis rarely occurs in methimazole users. We report a rare case of a 52-year-old female with toxic hepatitis after methimazole use that had past medical history of simvastatin induced liver injury.
