Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients
10.1016/j.apjtb.2016.12.008
- Author:
Atheer Awad MEHDE
1
;
Faridah YUSOF
1
;
Raha Ahmed RAUS
1
;
Atheer Awad MEHDE
2
;
Wesen Adel MEHDI
3
;
Layla Othman FARHAN
3
;
Jwan Abdulmohsin ZAINULABDEEN
4
;
Zaima Azira ZAINAL ABIDIN
5
;
Hamid GHAZALI
6
;
Azlina ABD RAHMAN
7
Author Information
1. Department of Biotechnology Engineering, College of Engineering, International Islamic University Malaysia
2. Department of Technical Medical Analysis, College of Health and Medical Technology, Middle Technical University
3. Department of Chemistry, College of Sciences for Women, University of Baghdad
4. Department of Chemistry, College of Sciences, University of Baghdad
5. College of Science, International Islamic University Malaysia
6. Department of Urology, Hospital Tengku Ampuan Afzan
7. Department of Pathology, Hospital Tengku Ampuan Afzan
- Publication Type:Journal Article
- Keywords:
E3 SUMO-protein ligase NSE2;
Nephrolithiasis;
Nitric oxide;
Peroxynitrite;
Total oxidant status
- From:Asian Pacific Journal of Tropical Biomedicine
2017;7(3):249-252
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prove probable relations between serum E3 SUMO-protein ligase NSE2 (NSMCE2) concentration, peroxynitrite related to oxidative stress in nephrolithiasis patients. Methods A total of 60 patients with nephrolithiasis and 50 healthy volunteers were involved in this study. Colorimetric method was used to detect blood urea, creatinine, uric acid, protein, albumin, total antioxidant status, total oxidant status, peroxynitrite, nitric oxide and oxidative stress index. Glutathione, NSMCE2 and superoxide dismutase were measured by ELISA. Results A significant increase in level of peroxynitrite, total oxidant status, NSMCE2 and oxidative stress index in patients was observed, while total antioxidant status and glutathione were significantly decreased. Conclusions The study concluded that serum NSMCE2 significantly correlated with peroxynitrite and oxidative stress in patients with nephrolithiasis.
