Dysregulation of Notch signaling related genes in oral lichen planus
10.1016/j.apjtb.2017.07.001
- Author:
Nunthawan NOWWAROTE
1
;
Thanaphum OSATHANON
1
;
Thanaphum OSATHANON
2
;
Thanaphum OSATHANON
3
Author Information
1. Mineralized Tissue Research Unit, Faculty of Dentistry, Chulalongkorn University
2. Department of Anatomy, Faculty of Dentistry, Chulalongkorn University
3. Craniofacial Genetics and Stem Cells Research Group, Faculty of Dentistry, Chulalongkorn University
- Publication Type:Journal Article
- Keywords:
Expression analysis;
Genes;
Notch signaling;
Oral lichen planus
- From:Asian Pacific Journal of Tropical Biomedicine
2017;7(7):666-669
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate a dysregulation of Notch signaling in oral lichen planus (OLP) using public available microarray dataset. Methods A mRNA expression profiling dataset from Gene Expression Omnibus was downloaded. Differential gene expression between OLP and normal oral epithelium was examined using NetworkAnalyst. The dysregulated genes related to Notch signaling were identified. Results Thirteen genes in Notch signaling pathway were significantly differential expressed between OLP and normal epithelium. OLP samples significantly increased the mRNA levels of HEYL, APH1B, CNTN1 and PSEN2. Whilst, ITCH, HES1, TLE2, DLK2, DTX2, NOTCH3, JAG2, RFNG, and SPEN were downregulated in OLP groups. Conclusions Notch signaling was dysregulated and may participate in pathophysiologic process in OLP.
