An in vitro evaluation of the antioxidant and antidiabetic potential of Sutherlandia montana E. Phillips & R.A. Dyer leaf extracts
10.1016/j.apjtb.2017.08.004
- Author:
Afolakemi Abibat ALIMI
1
;
Anofi Omotayo Tom ASHAFA
1
Author Information
1. Phytomedicine and Phytopharmacology Research Group, Department of Plant Sciences, University of the Free State, Qwaqwa Campus
- Publication Type:Journal Article
- Keywords:
Antidiabetic;
Antioxidant;
Phytochemicals;
Radical scavenger;
Sutherlandia montana
- From:Asian Pacific Journal of Tropical Biomedicine
2017;7(9):765-772
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the antioxidant and antidiabetic activities of Sutherlandia montana E. Phillips & R.A. Dyer leaf extracts using the in vitro model. Methods The antioxidant activities of aqueous, decoction, ethanol and hydro-ethanol extracts of the plant were determined using seven different assays; the antidiabetic potential was evaluated through the inhibition of key carbohydrate hydrolysing enzymes (α-amylase and α-glucosidase), while the modes of the enzymes inhibition were assessed using enzyme kinetic analysis. Results The ethanol extract exhibited the best scavenging activity (IC
