Citrus peel extract and powder attenuate hypercholesterolemia and hyperglycemia using rodent experimental modeling
10.1016/j.apjtb.2017.09.012
- Author:
Humaira ASHRAF
1
;
Masood Sadiq BUTT
1
;
Muhammad Jawad IQBAL
1
;
Hafiz Ansar Rasul SULERIA
1
;
Hafiz Ansar Rasul SULERIA
2
;
Hafiz Ansar Rasul SULERIA
3
Author Information
1. National Institute of Food Science & Technology, Faculty of Food, Nutrition & Home Sciences, University of Agriculture
2. UQ School of Medicine, Translational Research Institute, The University of Queensland
3. Department of Food, Nutrition, Dietetics & Health, Kansas State University
- Publication Type:Journal Article
- Keywords:
Citrus powder;
Efficacy study;
Functional foods;
Hypercholesterolemia;
Hyperglycemia;
Nutraceutical
- From:Asian Pacific Journal of Tropical Biomedicine
2017;7(10):870-880
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate hypocholesterolemic and hypoglycemic potential of citrus peel extract and powder using rodent experimental modeling. Methods Considering the fact, rat feeding trial was carried out for a period of 56 d to access the prophylaxis of citrus peel flavonoids by employing normal (study I), hyperglycemic (study II) and hypercholesterolemic (study III) rats. Each study was further divided into three groups to ensure the provision of selected diets, i.e., control, functional and nutraceutical diets. Each study was further divided into three groups to ensure the provision of selected diets, i.e., control, functional and nutraceutical diets. Results Declining trend for total cholesterol was observed in all studies with maximum reduction (8.55%) in rat group fed on nutraceutical diet in study III. Likewise, levels of low density lipoproteins and triglycerides reduced 11.39% and 7.89% respectively in hypercholesterolemic rats. Moreover, nutraceutical diet alleviated the sera glucose level by 8.96% in study II. Conclusions Conclusively, inclusion of citrus peel bioflavonoids in dietary therapies is a promising strategy to modulate lipidemic and glycemic attributes without imparting any deleterious effect on hematological parameters.
