Anti-hypercholesterolemic and anti-hyperglycaemic effects of conventional and supercritical extracts of black cumin (Nigella sativa)
10.1016/j.apjtb.2017.10.005
- Author:
Muhammad Jawad IQBAL
1
;
Masood Sadiq BUTT
1
;
Mir Muhammad NASIR QAYYUM
2
;
Hafiz Ansar RASUL SULERIA
3
;
Hafiz Ansar RASUL SULERIA
4
Author Information
1. National Institute of Food Science and Technology, Faculty of Food, Nutrition and Home Sciences, University of Agriculture
2. Department of Agriculture and Food Technology, Karakoram International University
3. UQ Diamantina Institute, Translational Research Institute, Faculty of Medicine, The University of Queensland
4. Department of Food, Nutrition Dietetics and Health, Kansas State University
- Publication Type:Journal Article
- Keywords:
Black cumin;
Functional food;
Hypercholesterolaemia;
Hyperglycaemia;
Nutraceuticals;
Supercritical extract
- From:Asian Pacific Journal of Tropical Biomedicine
2017;7(11):1014-1022
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the hypoglycaemic and hypocholesterolemic potential of conventional and supercritical extracts of black cumin. Methods Purposely, rat modelling was carried out for 2 months by designing three studies i.e. study I (normal rats), study II (hyperglycaemic rats) and study III (hypercholesterolemic rats). Each study was further divided into three groups based on diet i.e. control, functional diet (contained extract of black cumin prepared by using conventional solvent) and nutraceutical diet (contained extract of black cumin prepared by supercritical fluid extraction system). Results During whole trial, an abating trend was observed in the level of serum cholesterol with maximum reduction (12.8%) in nutraceutical group of study III. Low density lipoprotein and triglyceride level was also lowered maximum in study III as 17.1% and 11.6%, respectively. Whereas, highest decline in glucose level was in nutraceutical group of study II as 11.2%. Conclusions Inclusion of black cumin extracts in diet significantly lowers the occurrence of hyperglycaemia and hypercholesterolaemia. Furthermore, hypoglycaemic and hypocholesterolemic potential of nutraceutical diet is more prominent as compared to functional diet.
